![]() ![]() The question now, however, is how small this really is- how does this compare to those studies that did find a concerning effect from spike protein alone? In other words, a test that doesn’t get to this level of sensitivity- picograms per milliliter- will likely show that no spike antigens are detectable in the vaccinees. And intact spike is scarcely detectable in any of the participants (though there weren’t many). Additionally, we see quite clearly that the S1 and spike proteins both disappear from the blood despite their initial tiny concentration (note the day scale). A picogram is a trillionth of a gram, so this is a very small quantity indeed. Firstly, this assay is measuring picograms per milliliter quantities of the proteins. However we need to be aware of a few things. We know that the spike protein does not get secreted because it lacks the signal sequence for that, and the protein as specified by the mRNA is membrane bound. A key mechanistic point regarding the safety of the vaccines has been that the spike protein does not get to freely float around in the blood where it might be able to cause these deleterious effects we discussed earlier. This finding is initially a bit surprising. I’ll focus on those data which are shown below: The paper uses a technique called SIMOA to identify the S1 fragment of the spike protein and the intact spike protein in the plasma of vaccinees. Spike is also shown to activate the NLRP3 inflammasome which can induce inflammation that alerts the immune system to a problem (but can cause damage if allowed to go on uncontrolled) this can cause cells to undergo an inflammatory type of cell death called pyroptosis.Īnyway with that context, let’s discuss the paper. Additionally, in Buzhdygan et al, it’s shown that spike protein can affect the permeability of a model of the blood-brain barrier, which may lend clues as to some of the neurological diseases that seem to result from COVID-19. I have a detailed post on spike that I am working on to explain basically everything anyone ever wanted to know about the protein but in brief when spike protein interacts with the endothelial cells that line the blood vessels, it has been shown to reduce expression of the ACE2 protein (this makes some sense as ACE2 is how the virus enters cells, so naturally the cells are driven to evade infection) and this contributes to inflammation of the endothelial cells. Firstly, the reason some are concerned has to do with the discoveries that the spike protein alone may play a role in some of the disease manifestations of COVID (such as those explored here, and here). But actually there are several points about this paper that are very reassuring. A recent paper has found spike protein antigens in the blood of people who received the mRNA-1273 vaccine from Moderna, and this is naturally being spun to mean the vaccines are dangerous.
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